Mixed hemodiafiltration is a novel technique in which the traditional infusion modes of predilution and postdilution are carried out simultaneously in the same dialyzer to overcome the limits and risks of each and join their advantages. It is performed under the control of transmembrane pressure feedback, which constantly monitors blood and dialysate compartments and adjusts both the total infusion amount and its ratio in predilution and postdilution mode, in order to achieve the safest rheological and hydraulic conditions. The ensuing maximization of the convective fraction optimizes middle-molecule removal. The technical characteristics, method of application, and clinical results of mixed hemodiafiltration are described in this article.