The relatively recent introduction of corticotomies and piezocision has made it possible for orthodontists to accelerate tooth movement and thereby to shorten the length of orthodontic treatment. Specialists emphasizing a mechanistic concept have been debating the underlying basic biological mechanics of these new therapeutic tools with opposing specialists who support a biological conception. Our analysis of different publications on the subject suggests that the biological explanation, with its emphasis on the Regional Acceleratory Phenomenon (RAP), is correct. However, the majority of studies in this field are not based on the principle of evidence based medicine (EBM).