Valproate-induced vasculitis is seen as an adverse drug reaction in ratio that is less than 1/1000. Leukocytoclastic vasculitis can also occur internally. The cutaneous features of leukocytoclastic vasculitis are highly variable and may change rapidly. Valproic acid (VPA) is a chemical compound and an acid that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, atypical depression with hypersomnia. A 35-year-old woman presented with purpuric papules on her lower extremities was admitted to the Department of Dermatology and Venerology, University Hospital Centre Split. Clinical recognition of drug-induced vasculitic is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage (e.g. end-stage renal disease or pulmonary haemorrhage).