Short-term neurodevelopmental outcomes in neonates with congenital heart disease: the era of newer surgical strategies.
Copyright policy )Short-term neurodevelopmental outcomes in neonates with congenital heart disease: the era of newer surgical strategies.
The objective of this study was to determine neurodevelopmental outcomes up to 30 months of age in a cohort of neonates requiring surgical intervention without circulatory arrest for congenital heart disease and to correlate these outcomes with characteristics detected prior to hospital discharge.An observational cohort of surviving neonates who underwent surgical intervention without circulatory arrest for congenital heart disease between 2002 and 2003 was studied at a single tertiary care institution.Thirty-five patients were followed from 4 to 6 months of age until 24-30 months of age.Neuromotor abnormalities, use of special services, and degree of developmental delay at set intervals between 4 and 30 months of age were retrospectively obtained from clinical reports. The relationship between these outcomes and clinical characteristics prior to hospital discharge was analyzed.Those with neuromotor abnormalities prior to discharge were likely to have persistent abnormalities in muscle strength, tone, and symmetry until 4-6 months of age, odds ratio 6 (1.3-29). By 24-30 months of age, motor abnormalities or developmental delay occurred in 10 of 20 infants (50%), but were no longer significantly associated with predischarge findings.Infants undergoing surgical intervention for congenital heart disease are at risk for neurodevelopmental abnormalities, which may not become apparent until months after hospital discharge. Early impairment may also resolve over time. Close developmental follow-up in this high-risk cohort of patients is warranted.
- Stanford University United States
- Lucile Packard Children's Hospital United States
- University of California United States
Male, Developmental Disabilities, Cardiorespiratory Medicine and Haematology, Cardiovascular, Nervous System, California, Congenital, Child Development, Occupational Therapy, Risk Factors, Cardiovascular Medicine and Haematology, Odds Ratio, Child, Heart Defects, Pediatric, Age Factors, Skeletal, Patient Discharge, Heart Disease, Treatment Outcome, Motor Skills, Child, Preschool, Muscle, Female, Patient Safety, Heart Defects, Congenital, Clinical Sciences, Speech Therapy, Cardiovascular medicine and haematology, Clinical Research, Early Medical Intervention, Humans, Muscle Strength, Cardiac Surgical Procedures, Preschool, Muscle, Skeletal, Physical Therapy Modalities, Retrospective Studies, Biomedical and Clinical Sciences, Neurosciences, Infant, Newborn, Infant, Perinatal Period - Conditions Originating in Perinatal Period, Newborn, Logistic Models, Cardiovascular System & Hematology, Congenital Structural Anomalies
Male, Developmental Disabilities, Cardiorespiratory Medicine and Haematology, Cardiovascular, Nervous System, California, Congenital, Child Development, Occupational Therapy, Risk Factors, Cardiovascular Medicine and Haematology, Odds Ratio, Child, Heart Defects, Pediatric, Age Factors, Skeletal, Patient Discharge, Heart Disease, Treatment Outcome, Motor Skills, Child, Preschool, Muscle, Female, Patient Safety, Heart Defects, Congenital, Clinical Sciences, Speech Therapy, Cardiovascular medicine and haematology, Clinical Research, Early Medical Intervention, Humans, Muscle Strength, Cardiac Surgical Procedures, Preschool, Muscle, Skeletal, Physical Therapy Modalities, Retrospective Studies, Biomedical and Clinical Sciences, Neurosciences, Infant, Newborn, Infant, Perinatal Period - Conditions Originating in Perinatal Period, Newborn, Logistic Models, Cardiovascular System & Hematology, Congenital Structural Anomalies
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