The cytokine profile of blood (CPB) at the patients with chronic sepsis (CS) streptococcus or mixed (by a streptococcus and to staphylococcus etiology) was studied. To beginning of the treatment at intensifying of CS at the patients was detected the substantial increase of maintenance of proinflammatory (IL - 1β, IL - 2, IL - 6, TNF -α) cytokines (CК) in the blood serum at the moderate increase of antiinflammatory CK (IL-4). Thus, indexes, characterizing correlation pro- and antiinflammatory CК was rate, that testified to predominating of proinflammatory potencies of blood. Application in the complex treatment of the patients with CS combination of modern detoxic preparation reamberin and immunoactive preparation cycloferon promotes normalizations of CK maintenance in the blood and betweennesss by them. In a clinical plan the use of the reamberin and cycloferon combination provided acceleration of CS intensifying liquidation. Finding allow to consider pathogenetic reasonable and clinically perspective application of this preparations combination in treatment of the patients with CS.