Two siblings born to a morphine-addicted mother with morphine withdrawal syndrome were reported. The first child, a female, presented with irritability, jitteriness and watery diarrhea at three days of age. The second, a male, presented with jitteriness and irritability when twelve hours old. Both cases were managed with supportive care; phenobarbital was given for the first case. These two cases and the literature concerning neonatal morphine withdrawal syndrome are reviewed.