[Capping strategies in RNA viruses].
Copyright policy )[Capping strategies in RNA viruses].
Most viruses use the mRNA-cap dependent cellular translation machinery to translate their mRNAs into proteins. The addition of a cap structure at the 5' end of mRNA is therefore an essential step for the replication of many virus families. Additionally, the cap protects the viral RNA from degradation by cellular nucleases and prevents viral RNA recognition by innate immunity mechanisms. Viral RNAs acquire their cap structure either by using cellular capping enzymes, by stealing the cap of cellular mRNA in a process named "cap snatching", or using virus-encoded capping enzymes. Many viral enzymes involved in this process have recently been structurally and functionally characterized. These studies have revealed original cap synthesis mechanisms and pave the way towards the development of specific inhibitors bearing antiviral drug potential.
Models, Molecular, RNA Caps, Models, Biological, Protein Structure, Secondary, Acid Anhydride Hydrolases, Eukaryotic Cells, Animals, Humans, Nucleic Acid Conformation, RNA Viruses, RNA, Viral, RNA Processing, Post-Transcriptional, Protein Structure, Quaternary
Models, Molecular, RNA Caps, Models, Biological, Protein Structure, Secondary, Acid Anhydride Hydrolases, Eukaryotic Cells, Animals, Humans, Nucleic Acid Conformation, RNA Viruses, RNA, Viral, RNA Processing, Post-Transcriptional, Protein Structure, Quaternary
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).5 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!