Little is known about the occurrence of R. equi infection in humans at the present time. However, an increasing number of R. equi infections mainly in immunocompromised patients has been reported recently and R. equi is now considered an emerging zoonotic pathogen. Nevertheless sources and routes of human infection are not fully understood. Recently R. equi was detected in tissues of animals intended for human consumption. Clinical course of infection is often diversified and atypical. The physicians are frequently unaware of R. equi pathogenic potential due to little epidemiological and risk factors data.