In this article the regulatory factors of the epizootic process are considered and the spatial-temporal prognostication of rabies infection in the region is proposed on the basis of data on rabies morbidity among animals, the purchase of skins of carnivorous animals for 20-25 years, virological experiments on wild animals, calculation of the number of carnivores and small mammals, as meteorological observations. The study has shown that a variety of animal species serving as hosts for the virus and its population differences contribute to the stable existence of the infection. Rabies morbidity has been found to be positively linked with its preceding level, the number of wild animals, the height and hardness of the snow cover and negatively with the number of small mammals.