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https://doi.org/10.20772/cance...
Article . 1977 . Peer-reviewed
Full-Text: https://www.jstage.jst.go.jp/article/cancersci1959/68/5/68_5_553/_pdf
Data sources: Japan Link Center
https://pubmed.ncbi.nlm.nih.go...
Article . 1978
Data sources: Europe PubMed Central
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Comparative studies on the metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1977 English Publisher:The Japanese Cancer AssociationJournal:Gan, volume 68 (issn: 0016-450X, Copyright policy )
Authors: TOIDE, Hideki; AKIYOSHI, Hiroto; MINATO, Yoshihiro; OKUDA, Hiromichi; FUJII, Setsuro;

pmid: 22472

Comparative studies on the metabolism of 2-(tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.

Abstract

5=Fluorouracil inhibited DNA synthesis markedly using various DNA precursors such as deoxyuridine, orotic acid, uracil, and uridine except for thymidine. 2-(Tetrahydrofury)-5-fluorouracil (FT-207) did not inhibit DNA synthesis with any of the precursors tested. The metabolisms of 5-fluorouracil and FT-207 in mice and rats were studied. When administered intravenously 5-fluorouracil was rapidly degraded to fluoro-beta-alanine in both mice and rats, while at most 70% of FT-207 was slowly degraded after a prolonged period. The metabolites of FT-207 were found to be 5-fluorouracil and fluoro-beta-alanine in both species of animals. In vitro degradation of FT-207 into 5-fluorouracil was observed mainly in the microsomal fraction in the presence of NADPH. This result suggested that microsomal electron-transport system was concerned with the degradation of FT-207.

Keywords

Male, Mouse and rat, Alanine, DNA synthesis, 5-Fluorouracil, Nucleic Acid Precursors, DNA, Neoplasm, Neoplasms, Experimental, In Vitro Techniques, Rats, Mice, Microsomes, Liver, Animals, Tissue Distribution, Fluorouracil, Antitumor activity, 2-(Tetrahydrofuryl)-5-fluorouracil(FT-207), NADP, Tegafur

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
77
Average
Top 1%
Top 10%