To evaluate the frequency of complications in Laparoscopic cholecystectomies performed in Hamadan during 1997 to 2005.In this retrospective cross sectional study, 426 patients with cholecystitis who were admitted to Hamadan hospitals including Ekbatan, Tamin Ejtamaiee, Mobasher, Boali and Artesh and were subjected to laparoscopic cholecystectomy from 1997 to 2005 were evaluated.Of the 426 patients studied, 53 (12.44%) were male and 373 (87.56%) were female. The most frequent complication was retained stone (1.64%), followed by biliary duct injury (1.4%), bile leak (1.4%) and bleeding (1.17%).Laparoscopic cholecystectomy has become the gold standard technique in the treatment of gallbladder disease. However, special attention must be paid to high rate of bile duct injuries.