Powered by OpenAIRE graph
Found an issue? Give us feedback
addClaim

Tuberculous scrofula: Belfast experience.

Authors: Hedley-Whyte, John; Milamed, Debra;

Tuberculous scrofula: Belfast experience.

Abstract

The Belfast blitzes of 1941 are blamed in our family for the scrofula of my younger brother and sister and myself. Guinea pigs and rabbits at Musgrave Park proved that each of us had bovine derived TB infection caused by failure to pasteurize milk when tuberculin-tested milk was not available. The clinical head of Harvard Medical School’s anti-tuberculosis effort contacted his boss, Professor Maxwell Finland, who ascertained from Selman A. Waksman that his antibiotic streptothricin was bacteriostatic against TB but too toxic for humans. Finland, born 1902, knew Waksman (born 1888) well, each having emigrated from the Czarist-ruled Ukraine. Waksman , in 1942, had hopes for an analog to streptothricin he intended to name streptomycin: an antibiotic from Actinomyces griseus which had been culture-isolated in 1916 for his M.Sc. thesis. Streptomycin was still 6-9 months away from animal testing. The same Actinomyces species was also able to produce actinomycin C and D which was later supplied to Professor Sidney Farber of Harvard to start successful human cancer chemotherapy.

Accepted Manuscript

Country
United States
Related Organizations
Keywords

570, 590, Animals, Humans, History, 20th Century, Tuberculosis, Lymph Node, Bovine TB, Ireland, Orwell, Waksman

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    5
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Top 10%
Top 10%
Average
Related to Research communities
Cancer Research
Upload OA version
Are you the author of this publication? Upload your Open Access version to Zenodo!
It’s fast and easy, just two clicks!