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Problems of Endocrinology
Article . 1979
Data sources: Europe PubMed Central
Claim

[Regulation of the activity of 3', 5'-cyclic AMP phosphodiesterase by pancreatic hormones].

descriptionPublicationkeyboard_double_arrow_right Article 17 Sep 1979 Russian Journal:Problemy endokrinologii, volume 25 (issn: 0375-9660, Copyright policy )
Authors: N V, Zin'ko; L K, Starosel'tseva;

pmid: 223145

[Regulation of the activity of 3', 5'-cyclic AMP phosphodiesterase by pancreatic hormones].

Abstract

The character of the insulin effect on the activity of phosphodiesterase (PDE) cAMP of various subcellular localization was studied in the liver of normal and diabetic rats. As a result of kinetic investigations for PDE cAMP preparations of the plasma membranes there were obtained kinetic characteristics of two PDE forms, differing by their affinity to the substrate. For the both PDE cAMP forms stimulation of the activity with insulin was indicated. In examining the insulin effect on the activity of PDE cAMP of the liver of rats with streptozotocin-induced diabetes there was revealed a significant effect of the hormone on the kinetics of the enzyme with a high affinity to cAMP only.

Keywords

Male, Liver, 3',5'-Cyclic-AMP Phosphodiesterases, Swine, Hydrolysis, Cell Membrane, Animals, Insulin, Glucagon, Hormones, Streptozocin, Diabetes Mellitus, Experimental, Rats

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
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