To compare the effectivity and safety of second-trimester abortion induced by two different types of prostaglandins.Retrospective study.Department of Obstetrics and Gynecology, University Hospital Ostrava and Department of Obstetrics and Gynecology, University Hospital Olomouc.Retrospective analysis of 128 second trimester abortions induced by misoprostol and 82 second trimester abortions induced by dinoprost. Total length of abortion, failure of the method, need for instrumental revision of the uterine cavity, request for epidural analgesia and length of hospital stay were compared.In total 210 women were included. Misoprostol was used in 128 cases and dinoprost in 82 cases. The average gestational age was 18+1 in misoprostol group and 20+2 in dinoprost group. Ninety two percent of women with misoprostol aborted within 24 hours while in the dinoprost group it was 68%, withing 16 hours the number of completed abortions was 62% (misoprostol) versus 48% (dinoprost). The method failed in 2% of cases with misoprostol and 7% of cases with dinoprost.We conclude that induction of second-trimester abortion with the use of misoprostol is safe, quick, non-invasive and comfortable method with low frequency of complications and side effects.