Cardiovascular disease kills more adults in the United States each year than any other medical condition. Although these diseases are largely preventable, the number of newly diagnosed patients continues to climb. Angiography traditionally involves invasive catheter examinations, but recent advances have allowed computed tomography angiography (CTA) to supplant traditional angiography as a first-line diagnostic imaging modality to assess cardiovascular disease. Often used to diagnose vascular pathologies in symptomatic patients, CTA also is useful in early detection of coronary and peripheral artery diseases. CTA will play an increasingly important role in cardiovascular medicine as technological advances improve image data acquisition, processing speeds, and image reconstruction.