Regenerative medicine is widely noticed as advanced medicine that treats acquired or congenital tissue defects. In the field of oral surgery, congenital anomalies, tissue defects caused by tumor excision or trauma, periodontal diseases, or loss of teeth are regarded as the subjects of regenerative medicine. A maxillofacial area is expected to be applied to early clinical application, since it is lightly loaded compared to limbs or trunk and needs no large tissues. In this chapter, we will explain the current situation and future prospects of regenerative medicine, concerning maxillofacial bones, nasal cartilages, and periodontal tissues, and teeth.