Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis.

C, Pierre-Audigier; C, Surcouf; V, Cadet-Daniel; A, Namouchi; S, Heng; A, Murray; B, Guillard; B, Gicquel

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The International Jo...arrow_drop_down

The International Journal of Tuberculosis and Lung Disease

Article . 2012

Data sources: Europe PubMed Central

Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis.

descriptionPublicationkeyboard_double_arrow_right Article 29 May 2012 English Journal:The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, volume 16 (issn: 1815-7920,

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Authors: C, Pierre-Audigier; C, Surcouf; V, Cadet-Daniel; A, Namouchi; S, Heng; A, Murray; B, Guillard; +1 Authors

pmid: 22236923

Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis.

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Abstract

In a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3% in non-MDR strains. This emphasises the need for easy and rapid tests for identification of PZA-R for efficient treatment of MDR-TB.

Related Organizations

Institut Pasteur
France

Keywords

DNA, Bacterial, Genotype, Incidence, Antitubercular Agents, Mycobacterium tuberculosis, Pyrazinamide, Amidohydrolases, Mutation, Tuberculosis, Multidrug-Resistant, Humans, Cambodia, Fluoroquinolones, Retrospective Studies

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