Measurement of antibodies to herpesvirus types 1 and 2 in human sera by microradioimmunoassay.

M A, Jankowski; E E, Petersen; J F, Böcker

Found an issue? Give us feedback

Acta Virologicaarrow_drop_down

Acta Virologica

Article . 1978

Data sources: Europe PubMed Central

Measurement of antibodies to herpesvirus types 1 and 2 in human sera by microradioimmunoassay.

descriptionPublicationkeyboard_double_arrow_right Article 27 Jan 1978 English Journal:Acta virologica, volume 21 (issn: 0001-723X,

Copyright policy )

Authors: M A, Jankowski; E E, Petersen; J F, Böcker;

pmid: 22235

Measurement of antibodies to herpesvirus types 1 and 2 in human sera by microradioimmunoassay.

- Summary
- Subjects
- Metrics

Abstract

The binding of 125I-labelled anti-human antibodies against the fc IgG fragment to unlabelled antiviral immunoglobulins in the surface of infected cells was used to quantitate antibodies against herpes simplex virus type (HSV-1) and type 2 (HSV-2) in sera from patients with cervix carcinoma. The microradioimmunoassay technique (micro-RIA) proved to be 5-10 times more sensitive than the microneutralization test. Antibody titres determined by micro-RIA correlated with neutralizing antibody titres to both HSV-1 and HSV-2. The relative antibody titres to HSV-1 and HSV-2, as determined by micro-RIA, could be used to distinguish persons previously infected with HSV-2 by means of II/I indices.

Keywords

Diagnosis, Differential, Neutralization Tests, Radioimmunoassay, Humans, Simplexvirus, Uterine Cervical Neoplasms, Female, Herpes Simplex, Antibodies, Viral

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	3
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average