Chlamydophila felis is a common organism among cats and has been detected in up to 60% of cats with conjunctivitis or upper respiratory tract disease. Transmission is mainly caused by direct contact to symptomatic cats. Nevertheless, carriers without current clinical signs are able to shed the organism and, therefore, are a source of infection as well. Treatment and management of infection may be difficult as cats often live in close contact with shedding cats. The most common problem in multi-cat households is re-infection. The intracellular occurrence of Chlamydophila felis requires antibiotics that exhibit a good intracellular efficacy. In this review article, currently used treatment and management regimes are described and compared to each other.