The latrodectism is a rare poisoning rather unknown in Italy and some times fatal. The Authors in this latrodectism review intend to provide information about the Malmignatta spider Latrodectus tredecimguttatus: biology, Italian distribution and peculiarity of its venom. Here are reported the clinical picture of the toxic syndrome, with first principles of differential diagnosis. Afterwards, they face the treatment, illustrating the cases where they can use the antivenom, calcium gluconate or methocarbamol, with modalities, doses and administration stages.