Possible participation of glucocorticoid in elevation of 3',5'-cyclic AMP levels through inhibition of cyclic AMP phosphodiesterase.

Y, Tanigawa; A, Kitamura; M, Kawamura; M, Shimoyama; K, Fujii; Y, Kohri; I, Ueda

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Article . 1979

Data sources: Europe PubMed Central

Possible participation of glucocorticoid in elevation of 3',5'-cyclic AMP levels through inhibition of cyclic AMP phosphodiesterase.

descriptionPublicationkeyboard_double_arrow_right Article 28 Jul 1979 English Journal:Physiological chemistry and physics, volume 10 (issn: 0031-9325,

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Authors: Y, Tanigawa; A, Kitamura; M, Kawamura; M, Shimoyama; K, Fujii; Y, Kohri; I, Ueda;

pmid: 220644

Possible participation of glucocorticoid in elevation of 3',5'-cyclic AMP levels through inhibition of cyclic AMP phosphodiesterase.

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Abstract

Administration of prednisolone and cholate to rats elevated levels of cAMP (adenosine 3',5'-cyclic monophosphate) by 1.5- to 2.0-fold. Compounds such as prednisolone, hydrocortisone, cholate, and deoxycholate were found to be potent inhibitors of partially purified cAMP phosphodiesterase prepared from rat liver. Kinetic analysis showed that the prednisolone inhibition was noncompetitive with a Ki of 8.9 x 10(-4) M. These results suggest that in addition to increasing DNA-dependent RNA polymerase activity in vivo, a large application of glucocorticoid may incur elevation of intracellular cAMP levels.

Keywords

Male, Hydrocortisone, Prednisolone, Cholic Acids, Rats, Liver, 3',5'-Cyclic-AMP Phosphodiesterases, Cyclic AMP, Animals, Glucocorticoids, Deoxycholic Acid

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