Research on sex chromosome aberrations has made considerable progress. There are evidences that possession of an extra X chromosome may affect the mental health of an individual. All the male schizophrenia patients registered during the period of study, who were not under treatment, constituted the patient sample. They numbered two hundered eighty seven. A properly matched control sample of two hundred thirty three healthy persons was also examined. Nuclear sexing and Karyotype was done for (a) all the chromatin positive cases in patient as well as control sample (b) ten per cent cases of normal XY individual's of patient sample(28) and control sample (23) Photography was done for the positive slides. The patients who showed chromation positive XXY pattern were studied further clinically along with Rorschach test and Bhatia battery. The schizophrenics showed more prevalence of chromatin positive than the control sample.