
With the publication of l"Introduction à l'étude de la médecine expérimentale (Introduction to the Study of Experimental Medicine) in 1865, Claude Bernard opened up a new concept in experimental methodology. By stressing the essential link between clinical observation, exploration of the "internal medium", and animal studies, he established the founding principles of clinical research.
Biomedical Research, Concept Formation, Publications, Animals, Humans, History, 19th Century, France, Models, Theoretical
Biomedical Research, Concept Formation, Publications, Animals, Humans, History, 19th Century, France, Models, Theoretical
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