["The inflammasomes"].
Copyright policy )["The inflammasomes"].
Inflammation is a host adaptational response to cell injury caused by various exogenous and endogenous stimuli. IL-1β, which is an important proinflammatory cytokine secreted at the site of cellular injury, plays an important role in inflammation. Inflammasome is an intracellular multi-protein complex that mediates caspase-1-dependent processing of IL-1β. In this review, inflammasome function and its dysregulation are discussed in relation to autoinflammatory diseases.
- Shinshu University Japan
Inflammasomes, Calcium-Binding Proteins, Caspase 1, Hereditary Autoinflammatory Diseases, Interleukin-1beta, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, NLR Proteins, Pyrin, CARD Signaling Adaptor Proteins, DNA-Binding Proteins, Cytoskeletal Proteins, NLR Family, Pyrin Domain-Containing 3 Protein, Humans, Inflammation Mediators, Apoptosis Regulatory Proteins, Carrier Proteins, Adaptor Proteins, Signal Transducing
Inflammasomes, Calcium-Binding Proteins, Caspase 1, Hereditary Autoinflammatory Diseases, Interleukin-1beta, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, NLR Proteins, Pyrin, CARD Signaling Adaptor Proteins, DNA-Binding Proteins, Cytoskeletal Proteins, NLR Family, Pyrin Domain-Containing 3 Protein, Humans, Inflammation Mediators, Apoptosis Regulatory Proteins, Carrier Proteins, Adaptor Proteins, Signal Transducing
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