[Expression of deleted in liver cancer 1 and phosphorelated focal adhesion kinase in breast cancer].

Yun, Feng; Hui-xing, Zhou; Jun-hong, Li; Zhen-yu, Li; Wei-gang, Cheng; Meng-lin, Jin; Liang, He

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Article . 2013

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[Expression of deleted in liver cancer 1 and phosphorelated focal adhesion kinase in breast cancer].

descriptionPublicationkeyboard_double_arrow_right Article 02 May 2013Journal:Nan fang yi ke da xue xue bao = Journal of Southern Medical University, volume 31 (issn: 1673-4254,

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Authors: Yun, Feng; Hui-xing, Zhou; Jun-hong, Li; Zhen-yu, Li; Wei-gang, Cheng; Meng-lin, Jin; Liang, He;

pmid: 21868344

[Expression of deleted in liver cancer 1 and phosphorelated focal adhesion kinase in breast cancer].

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Abstract

To analyze the expression of deleted in liver cancer 1 (DLC1) and phosphorelated focal adhesion kinase (p-FAK) in breast cancer tissue to further understand the molecular mechanisms of the carcinogenesis and metastasis of breast cancer.Immunohistochemistry was employed to determine the protein level of DLC1 and p-FAK in 61 breast cancer, 30 benign breast disease and the adjacent normal breast tissues.The positivity rates of DLC1 differed significantly between breast cancer, benign and normal tissues (34.43%, 80.00% and 76.67%, respectively, P0.05).The abnormal expression of DLC1 and p-FAK might participate in the carcinogenesis, progression, and metastasis of breast cancer. The role of DLC1 and p-FAK might be related to the regulation of progestone. DLC1 and p-FAK may serve as candidate markers for early diagnosis, prognostic evaluation and target treatment of breast cancer.

Keywords

Adult, Tumor Suppressor Proteins, Carcinoma, Ductal, Breast, GTPase-Activating Proteins, Breast Neoplasms, Middle Aged, Prognosis, Focal Adhesion Kinase 1, Lymphatic Metastasis, Humans, Female, Phosphorylation, Receptors, Progesterone

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