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Segmentación de tejido cancerígeno en imágenes de histopatología tintada con Hematoxilina-eosina usando aprendizaje profundo

Authors: Pérez Calavia, Daniel;

Segmentación de tejido cancerígeno en imágenes de histopatología tintada con Hematoxilina-eosina usando aprendizaje profundo

Abstract

[Resumen] Uno de los campos que ha visto más actividad en los últimos años ha sido el uso de técnicas de deep-learning o aprendizaje profundo en medicina. Gracias a la gran cantidad de datos disponibles, a un continuo aumento de la capacidad de cálculo y a una mejora continua en los algoritmos de aprendizaje usados, no es de extrañar que el uso de estas técnicas en sistemas de diagnóstico asistido por ordenador sea cada vez más común. Debido a que el cáncer de mama es el cáncer con más prevalencia en las mujeres, cualquier mejora en el diagnostico tendría un gran efecto beneficioso en la lucha con la enfermedad. Por ello en este trabajo se desarrolla un sistema de segmentación sobre imágenes histológicas de cáncer de mama tintadas con H&E sobre un dataset de referencia internacional aplicando técnicas de deep-learning. En concreto usamos una arquitectura muy popular en el campo de segmentación de imágenes médicas, además del desarrollo de un sistema de selección de parches para procesar imágenes de grandes dimensiones, un procesamiento de los datos de entrada mediante técnicas como data augmentation y un sistema para sustituir parches ya aprendidos. A través de las iteraciones por las que pasa el desarrollo, se muestra la evolución de estos y otros sistemas y se analizan los efectos de los cambios propuestos en los resultados obtenidos.

[Abstract] One of the fields that has seen more activity in recent years has been the use of deeplearning techniques in medicine. Due to the large amount of data available, an increase in computing capacity and improvement in the learning algorithms used, it is not surprising that the use of these techniques in computer-aided diagnostic systems is becoming more and more common. Because breast cancer is the most prevalent cancer in women, any improvement in diagnosis would have a great beneficial effect in fighting the disease. For this reason, in this work we develop a system for the segmentation of cancerous tissue in hystopathology images tinted with H&E on a dataset of international reference using deep-learning techniques. In particular, we use a very popular in the field of medical image segmentation, in addition we develop a patch selection system in order to process large images, a data processing pipeline using data augmentation techniques and a system that substitutes already learned patches. Through multiple iterations we show the evolution of the developed systems and analyze the effects of the proposed changes on the results.

Traballo fin de grao (UDC.FIC). Enxeñaría Informática. Curso 2021/2022

Country
Spain
Related Organizations
Keywords

Medical image, Deep Learning, Redes convolucionales, Aprendizaje profundo, Histología tintada, Whole-Slide-Images, Convolutional Networks, Deep learning, Imagen médica, Stained histology, Convolutional networks

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Related to Research communities
Cancer Research