Previous studies have shown the cost benefit of fractional flow reserve (FFR)--guided coronary revascularization in the patient with multivessel borderline coronary artery stenoses. However; they have been performed in the Bare-metal stent era. It is a challenge to demonstrate the benefit of the FFR-guided coronary revascularization in the patient with multivessel coronary disease (MVD) in the drug-eluting era in Thai patients.Forty-nine patients with MVD (71 stenotic vessels) underwent FFR-guided revascularization (FFR group) compared with forty-nine patients with MVD (79 stenotic vessels) underwent traditional PCI (Traditional group) on the basis of visual estimation of the stenotic lesion. PCI has been performed in the FFR group patient with FFR value or = 0.75 continued on medical treatment. The event rates of chest pain, repeat revascularization, hospitalization, myocardial infarction and death were compared between both groups. Total costs incurred in the catheterization laboratory, including the cost of stent, balloon, pressure guide wire, contrast media and other supplies, were computed between both groups.In FFR group: in 46 vessels, FFR was 0.87 +/- 0.06 and PCI was avoided, the other 25 vessels, baseline FFR was 0.65 +/- 0.09 and were underwent PCI. Two patients proceed CABG In the traditional PCI group: 79 vessels were underwent PCI. In comparison of event free survival between the FFR and the traditional PCI groups during follow-up (mean follow-up 8.27 +/- 5.45 vs. 9.49 + 5.39 months), they were not different in MACE, chest pain, repeat revascularization, hospitalization, myocardial infarction and death (8.2% vs. 13.3%, p = 0.33). The average total cost saving per patient was 63,290 Baht (p < 0.001).For patients with borderline MVD, FFR-guided coronary revascularization with drug eluting stent placement could save a total cost per patient at 63,290 Bath without compromising safety.