A study was made of the therapeutic efficacy of nootropic agents in multimodality treatment of 62 patients with traumatic epilepsy. The treatment efficacy was appraised with regard to the time-course of changes in psychopathological symptomatology. The data obtained have been processed statistically according to criteria for the signs. When applied in multimodality treatment of patients with traumatic epilepsy the nootropic agents turned out most efficacious for the psycho-organic syndrome and for the status of deranged consciousness. The use of the nootropic agents as part of rehabilitation therapy allows improvement of the secondary prophylaxis of traumatic epilepsy.