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[The concept of incretins and the physiological roles of incretins].

descriptionPublicationkeyboard_double_arrow_right Article 08 Jul 2011 Japanese Journal:Nihon rinsho. Japanese journal of clinical medicine, volume 69 (issn: 0047-1852, Copyright policy )
Authors: Ryuzo, Kawamori;

pmid: 21595259

[The concept of incretins and the physiological roles of incretins].

Abstract

Incretins, exemplified by glucagon-like peptide 1(GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate glucose-dependent insulin secretion. Both GLP-1 and GIP also promote beta cell proliferation and inhibit apoptosis, leading to expansion of beta cell mass. GLP-1, but not GIP, controls glycemia via additional actions on glucose sensors, inhibition of gastric emptying, food intake and glucagon secretion.

Related Organizations
Keywords

Diabetes Mellitus, Type 2, Humans, Incretins

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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