Territorial Impact Assessment of Territorial Cohesion in Italy is the main topic as well as the title of this special issue, which makes available the intermediate results of an Italian National Research Project PRIN2015 which will be closed in February 2020 (Project 73. PI Maria Prezioso - 20155NXJ8T - SH3 “Territorial Impact Assessment della coesione territoriale delle regioni italiane. Modello, su base place evidence, per la valutazione di policy rivolte allo sviluppo della green economy in aree interne e periferie metropolitane”). From February 2017, ten academic groups acting in collaborative partnership have discussed and implemented visions by literature review and experimental application of an innovative methodological approach, methods and tools, producing data, mapping and geographical studies. - is intensive activity, which is involving more than sixty researchers, national and regional policy/decision makers, stakeholders and practitioners is already collected in a book (Prezioso, ed., Quale Territorial Impact Assessment della coesione territoriale nelle regioni italiane. La concettualizzazione del problema, Bologna, Pàtron, 2018). It preceded as theoretical contribution and methodological addresses the applied phase presented in this issue, which represents the intermediate work of the research units.