The construct of sensation seeking has been studied extensively, as indicated by the more than 4000 publications displayed by PsycINFO with this search term at the beginning of 2016. First, we presented Zuckerman’s (1994) definition of sensation seeking and the main difference with impulsivity. Then we highlighted the biological correlates of sensation seeking, the differences in sensation seeking correlated with demographic factors, and some characteristics of high sensation seekers, including cognitive features and attitudes. Next, we present the activities that can be associated with sensation seeking, pointing out that these activities can either be socially acceptable or risk- and crime-related. Finally, we point out that substance-related and behavioral addictions are the clinical conditions most studied in relation to sensation seeking, especially in adolescents and youths.