Immunocytochemical and lectin-binding studies on Lafora bodies.
Copyright policy )Immunocytochemical and lectin-binding studies on Lafora bodies.
Antibodies to a range of intermediate filaments and lectins specific for several different carbohydrates were used to study Lafora bodies in two cases of Lafora disease. Positive staining of Lafora bodies was found with antibodies to 160 KD and 200 KD neurofilaments and to desmin. Positive staining with concanavalin A showed different patterns of inhibition with glucose and mannose, suggesting that the latter hexose contributes to the 10% non-glucose carbohydrate content of these bodies.
Immunoenzyme Techniques, Inclusion Bodies, Lectins, Carbohydrates, Intermediate Filaments, Humans, Epilepsies, Myoclonic, Antibodies, Desmin
Immunoenzyme Techniques, Inclusion Bodies, Lectins, Carbohydrates, Intermediate Filaments, Humans, Epilepsies, Myoclonic, Antibodies, Desmin
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