Staphylococcus epidermidis is an emerging nosocomial pathogen. Due to its increasing incidence in many countries of the world it is a burning issue now a day. There is marked geographic variation in prevalence of methicillin resistant Staphylococcus epidermidis. Though it as is an endogenous human skin flora, it is therefore easily transmissible in the hospital environment well as in a community. Skin of patients and health care workers, medical equipment, clothing of personnel and environment surfaces can be sources of antibiotic-resistant S. epidermidis strains. This opportunistic pathogen causing different types of infections linked to implanted medical devices especially in immunocompromised patients. Early and specific diagnosis is important to ensure a favourable outcome. So Staphylococcus epidermidis found in culture should not always be ignored as contaminant and proper medical treatment and preventive guidelines should be applied against this alarming pathogen.