[PI3K inhibitor].

Seiji, Yano; Shinji, Takeuchi; Tadaaki, Yamada; Hisatsugu, Mouri; Kaname, Yamashita; Koushiro, Ohtsubo; Kazuo, Yasumoto

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Article . 2011

Data sources: Europe PubMed Central

[PI3K inhibitor].

descriptionPublicationkeyboard_double_arrow_right Article 29 Mar 2011 Japanese Journal:Gan to kagaku ryoho. Cancer & chemotherapy, volume 38 (issn: 0385-0684,

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Authors: Seiji, Yano; Shinji, Takeuchi; Tadaaki, Yamada; Hisatsugu, Mouri; Kaname, Yamashita; Koushiro, Ohtsubo; Kazuo, Yasumoto;

pmid: 21368457

[PI3K inhibitor].

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Abstract

PI3K-Akt is an important signal transduction pathway which acts downstream from various growth factor receptors. The PI3K-Akt pathway is activated in many types of cancers by several mechanisms, including growth factor receptor activation, loss of PTEN, and PI3K gene mutations. Therefore, PI3K is thought to be an ideal therapeutic target. A large number of PI3K inhibitors are being developed and evaluated in clinical trials.

Related Organizations

Kanazawa University
Japan

Keywords

Phosphatidylinositol 3-Kinases, Neoplasms, Humans, Molecular Targeted Therapy, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Phosphoinositide-3 Kinase Inhibitors, Signal Transduction

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