[G3BP: a promising target for cancer therapy].
Copyright policy )[G3BP: a promising target for cancer therapy].
G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation. G3BP plays a general role in the signal pathways of cell proliferation, differentiation, apoptosis and RNA metabolism. It has been shown to be over-expressed in a number of human malignancies and has a close relationship with tumor invasion and metastasis. Given that it has been implicated in several pathways that are known to be involved in cancer biology, G3BP may provide a new target for cancer therapy.
- Chinese Academy of Medical Sciences & Peking Union Medical College China (People's Republic of)
GTPase-Activating Proteins, Molecular Sequence Data, DNA Helicases, Peptide Fragments, src Homology Domains, Drug Delivery Systems, RNA Recognition Motif Proteins, ras GTPase-Activating Proteins, Neoplasms, Animals, Humans, Phosphorylation, Carrier Proteins, Poly-ADP-Ribose Binding Proteins, RNA Helicases, Signal Transduction
GTPase-Activating Proteins, Molecular Sequence Data, DNA Helicases, Peptide Fragments, src Homology Domains, Drug Delivery Systems, RNA Recognition Motif Proteins, ras GTPase-Activating Proteins, Neoplasms, Animals, Humans, Phosphorylation, Carrier Proteins, Poly-ADP-Ribose Binding Proteins, RNA Helicases, Signal Transduction
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