The results are presented of treatment with gangliosides (Cronassial) in 5 patients with late postpoliomyelitis syndrome. Clinical and electrophysiological examination were done before and after three months of treatment. Only subjective improvement was found. A year-long follow-up failed to fluid progression of the signs and symptoms that, formerly, were progressing slowly. It seems that Cronassial administration (in larger doses and for a longer time) is justified in patients with peripheral motor neuron lesion.