The purpose of this study was to gain a deeper understanding of factors affecting fluoride-ion release from a newly developed fluoride releasing resin (F-resin) under various conditions. Both higher temperature and longer immersion times resulted in a greater amount of fluoride ion released from this material, whereas thermal cycling did not accelerate the fluoride release. It was also found that the amount of released fluoride ion increased with increase in pH. The experiments performed also demonstrated that the fluoride release rate was reduced by polishing or heating the test disc of F-resin. Although the amount of released fluoride ion varied with each experimental conditions employed, a fluoride ion release was always observed under all experimental conditions.