Genetic polymorphism of immunoglobulin G in the mink. VI. A regulatory gene controlling the expression of the gamma-chain constant region allotype of mink immunoglobulin.

I I, Fomicheva; , Volkova OYu

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Experimental and Cli...arrow_drop_down

Experimental and Clinical Immunogenetics

Article . 1991

Data sources: Europe PubMed Central

Genetic polymorphism of immunoglobulin G in the mink. VI. A regulatory gene controlling the expression of the gamma-chain constant region allotype of mink immunoglobulin.

descriptionPublicationkeyboard_double_arrow_right Article 10 May 1991 English Journal:Experimental and clinical immunogenetics, volume 7 (issn: 0254-9670,

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Authors: I I, Fomicheva; , Volkova OYu;

pmid: 2128024

Genetic polymorphism of immunoglobulin G in the mink. VI. A regulatory gene controlling the expression of the gamma-chain constant region allotype of mink immunoglobulin.

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Abstract

We describe here the inheritance of H6, one of the six known allotypes of the gamma-chain constant region of mink immunoglobulin (IgG). H6 is not present in minor concentrations in the serum, and its phenotypic expression is stable. However, in offspring of some of (H6-)X(H6-) crosses. H6 appeared unexpectedly and, by contrast, it disappeared in some H6+/H6+ homozygote offspring. Based on pedigree analysis, a transregulation of H6 expression in the serum by an autosomal recessive gene not linked to the structural allotype gene is postulated.

Related Organizations

Institute of Cytology and Genetics
Russian Federation

Keywords

Polymorphism, Genetic, Genes, Immunoglobulin, Immunoglobulin gamma-Chains, Genes, Recessive, Pedigree, Phenotype, Gene Expression Regulation, Mink, Immunoglobulin G, Genes, Regulator, Animals, Immunoglobulin Allotypes

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