Marine derived drugs are emerging with promises to positively intervene in a range of diseases including viral, bacterial, fungal, and to even some forms of cancers. Hemolymph of several molluscs are of particular interest for their immunomodulatory properties that enhance their anti-microbial and anti-cancerous mechanisms. Our research aims to uncover the immunological effects of Haliotis rubra hemolymph, purified hemocyanin and hemolymph permeate. Their immunomodulatory properties can be key to treating Herpes Simplex Virus -1, HSV-1, infected patients and prostate cancer patients. In this study, we cultured HaCat cells and Human oral primary and prostate cancer cell line (PC-3) to observe immunomodulatory effects of the extracts on such form of cancer. Treatment with variable concentrations of abalone sera, purified hemocyanin and the sera/hemolymph were carried out. Results show a 50% inhibition in Interleukin-6 (IL-6) expression, 21% inhibition in Interleukin-8 (IL-8) . There is an observed inhibition of IL-6 expression in permeate, AH and sera treated PC-3. Additionally, the effects also extend to IL-8. The most significant results were obtained for primary oral keratinocytes treatment with the abalone sera yielding a sharp 35 fold increase in IL-8 concentration and 23 fold increase in IL-6 concentration as compared to the untreated control. To summarize: hemolymph, purified hemocyanin and hemolymph permeate targets IL-6 and IL-8 , that will potentially help HSV-1 infected and prostrate cancer patients. Whole hemolymph permeate induces highest degree of cytokine modulation in all cell types. The permeate is found to predominantly consist of hemocyanin fragments of various sizes . Therefore, broken hemocyanin fragments, rather than whole hemocyanin molecule, has greater immunomodulatory properties. HaCat cells do not fit as a model for IL-6 and IL-8 modulation studies, although targeted modulation of these cytokines are also exhibited here on hemolymph treatments.