Congenital talipes equinovarus, or clubfoot, is a condition where the foot develops in equinus (pointing down), adductus (pointing in) and varus (twisting in). It occurs in 1 per 1000 births and without intervention leads to life-long disability and pain. This thesis examines several key areas in current research of clubfoot. Chapter 1 provides a broad overview of the definition, aetiology, assessment and management of clubfoot. Chapter 2 reports the findings of a 12 month prospective study comparing children with relapsing clubfoot requiring tibialis anterior tendon transfer to children with clubfoot not requiring tibialis anterior tendon transfer. Chapter 3 evaluates the differences in clinical severity between unilateral and bilateral cases of clubfoot and the statistical implications of examining data per foot rather than data per person. Chapter 4 examines the severity and correlation of right and left feet of bilateral cases of clubfoot and the unit of analysis error implications for future research in this sub-group. Chapter 5 presents a Cochrane Systematic Review examining all interventions for clubfoot utilising statistical models which account for the correlation in right and left feet of bilateral clubfoot cases. Chapter 6 summarises the results of Chapters 2-5 and discusses the implications for future research into the assessment, analysis and management of clubfoot deformity.