The study has been done in 30 women with the resistant ovary syndrome diagnosed by laparoscopy, laparotomy and histologic examination of ovarian biopsy samples. Genetic study identified the feminine phenotype and genotype (46,XX). Estradiol levels corresponded to those seen in the follicular menstrual phase, prolactin levels were normal, and gonadotropin levels were above basal values and were several fold above the ovulatory peak, when tested with luteinizing hormone-releasing factor in 7 patients and after estrogen challenge in 5 patients. The tests indicated an adequate adenohypophyseal response and intact feedback mechanisms between the hypothalamic pituitary system and gonadal steroids, as confirmed by electroencephalography.