Acute generalized exanthematous pustulosis is a cutaneous reaction pattern typically precipitated by medication exposure. It has an estimated incidence of 1 to 5 cases per million per year and can occur in all age groups. Diagnosis is based on typical rash morphology, histopathology, and clinical course. Treatment consists of withdrawing the causative agent and providing supportive care. Prognosis for full recovery is excellent. Patients should be counseled to avoid any future use of the causative medication.