When moxibustion is applied to a certain acupoint in the patient, a regional heat sensitive reaction may be found. In the present paper, the authors expound its conception and appearing regularities, its relationship with the "arrival of qi" of Chinese medicine, and its clinical application in guiding acupoint selection and heat-stimulation quantity. Heat sensitive reaction during moxibustion ("heat sensitive moxibustion") is frequently seen in people undergoing pathological conditions and correlates highly with the diseases. It characterizes in dynamic changes in the location along with the state of the disorders and in being not always to coincide with the standard meridian acupoint location. The heat sensitive phenomenon of moxibustion is one of the manifestations in the activated functional activities of meridian of Chinese medicine just like the arrival of the qi caused by acupuncture stimulation. It is also a sign of activation of the human endogenous functional regulative system. Therefore, thinking highly of the heat sensitive reaction of moxibustion is the key point for raising the curative effect in clinical practice.