[Expression and significance of P311 and ITGB4BP in non-small cell lung cancer].

Chun-lan, Tang; Shun-zong, Yuan; He-ping, Yang; Qing-liang, Wang; Rong, Zhang

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Article . 2011

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[Expression and significance of P311 and ITGB4BP in non-small cell lung cancer].

descriptionPublicationkeyboard_double_arrow_right Article 06 Jun 2011Journal:Zhonghua zhong liu za zhi [Chinese journal of oncology], volume 32 (issn: 0253-3766,

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Authors: Chun-lan, Tang; Shun-zong, Yuan; He-ping, Yang; Qing-liang, Wang; Rong, Zhang;

pmid: 21029697

[Expression and significance of P311 and ITGB4BP in non-small cell lung cancer].

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Abstract

The aim of this study was to investigate the expression and significance of P311 and ITGB4BP in non-small cell lung cancer (NSCLC).Tissue microarrays were prepared from 80 NSCLC specimens and examined by immunohistochemistry.The positive rates of P311 and ITGB4BP expression were 77.5% (62/80) and 82.5% (66/80), respectively. The double positive expression rate was 73.8% (59/80). The consistency rate was 87.5%, and there was a significant consistency between P311 and ITGB4BP expressions (Kappa = 0.611, P < 0.001).There may be a new signaling pathway P311-ITGB4BP in NSCLC, and it may regulate the lung cancer cell migration.

Related Organizations

Southwest Hospital
China (People's Republic of)
Third Military Medical University
China (People's Republic of)

Keywords

Oncogene Proteins, Lung Neoplasms, Paraffin Embedding, Nerve Tissue Proteins, Adenocarcinoma, Immunohistochemistry, Tissue Array Analysis, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Humans, Eukaryotic Initiation Factors, Signal Transduction

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