To detect the level changes of plasma N-terminal B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) in patients with heart failure (HF) and explore their clinical correlations and prognostic significances.A total of 100 cases of HF patients were selected along with 20 age and gender-matched controls. The levels of NT-proBNP and hs-CRP were tested.The levels of NT-proBNP were significantly higher in HF patients than the controls. And the difference was statistically significant (P < 0.01). In congestive HF patients, the elevating magnitude of plasma NT-proBNP level showed a significantly positive correlation with that of hs-CRP during the same period.(1) The level of NT-proBNP is significantly higher in HF patients. And it can be used as one of auxiliary diagnostic indicators. (2) The level of NT-proBNP in conjunction with hs-CRP can predict the prognosis of HF patients.