[Pharmacokinetics of hopantenic acid upon peroral administration].

M V, Karlina; O N, Pozharitskaia; V M, Kosman; A N, Shikov; M A, Lazukina; G I, D'iachuk

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Экспериментальная и ...arrow_drop_down

Экспериментальная и клиническая фармакология

Article . 2010

Data sources: Europe PubMed Central

[Pharmacokinetics of hopantenic acid upon peroral administration].

descriptionPublicationkeyboard_double_arrow_right Article 16 Nov 2010 Russian Journal:Eksperimental'naia i klinicheskaia farmakologiia, volume 73 (issn: 0869-2092,

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Authors: M V, Karlina; O N, Pozharitskaia; V M, Kosman; A N, Shikov; M A, Lazukina; G I, D'iachuk;

pmid: 20919560

[Pharmacokinetics of hopantenic acid upon peroral administration].

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Abstract

A simple, specific and sensitive RP-HPLC method with UV detection for the determination of hopantenic acid in human blood plasma has been developed. The pharmacokinetics of drug pantocalcin upon single peroral administration was investigated on 18 healthy volunteers. The peak of hopantenic acid in blood plasma was achieved at 1.56 h and the elimination half life was 6.68 h. No hopantenic acid in blood plasma is found in 48 h.

Keywords

Adult, Male, Administration, Oral, Humans, Female, Chromatography, High Pressure Liquid, Nootropic Agents, Pantothenic Acid, gamma-Aminobutyric Acid, Half-Life

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