[Experimental study of cytoprotector effect of succinate-containing drugs on functional activity of liver].

D S, Sukhanov; A L, Kovalenko; M G, Romantsov; A Iu, Petrov; T N, Savateeva

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Экспериментальная и ...arrow_drop_down

Экспериментальная и клиническая фармакология

Article . 2010

Data sources: Europe PubMed Central

[Experimental study of cytoprotector effect of succinate-containing drugs on functional activity of liver].

descriptionPublicationkeyboard_double_arrow_right Article 16 Nov 2010 Russian Journal:Eksperimental'naia i klinicheskaia farmakologiia, volume 73 (issn: 0869-2092,

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Authors: D S, Sukhanov; A L, Kovalenko; M G, Romantsov; A Iu, Petrov; T N, Savateeva;

pmid: 20919557

[Experimental study of cytoprotector effect of succinate-containing drugs on functional activity of liver].

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Abstract

Hepatoprotective effect of metabolism correctors has been studied on the model of experimental viral and toxic damage of the liver. Reamberin-based substrate compositions (cytoflavin and remaxol) exhibit antihypoxic effect, antioxidant activity, and cytoprotective action on the background of metabolic effect. Based on these results, the indicated preparations are recommended for clinical trials on acute and chronic viral liver disorders.

Keywords

Mice, Meglumine, Liver, Cytoprotection, Hepatitis, Viral, Animal, Animals, Succinates, Chemical and Drug Induced Liver Injury, Antioxidants

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