[Anti-arrhythmic effects of matrine].
Copyright policy )[Anti-arrhythmic effects of matrine].
Matrine (MT) is an alkaloid isolated from Sophra alopecuroids L. The LD50 of MT iv to mice was 72.1 mg/kg (95% CL 68.2-76.5 mg/kg). MT had significant effects on different experimental models of arrhythmias induced by aconitine, barium chloride or coronary ligation. The ECG of anesthetized rats was significantly changed after iv of MT. The HR was retarded and the PR and QTc intervals were prolonged.
- Beijing Chao-Yang Hospital China (People's Republic of)
Male, Aconitine, Barium Compounds, Arrhythmias, Cardiac, In Vitro Techniques, Rats, Alkaloids, Chlorides, Barium, Heart Rate, Animals, Female, Matrines, Anti-Arrhythmia Agents, Quinolizines, Muscle Contraction
Male, Aconitine, Barium Compounds, Arrhythmias, Cardiac, In Vitro Techniques, Rats, Alkaloids, Chlorides, Barium, Heart Rate, Animals, Female, Matrines, Anti-Arrhythmia Agents, Quinolizines, Muscle Contraction
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