[Inhibitory effects of LHRH on ovarian LH receptors in rats].
[Inhibitory effects of LHRH on ovarian LH receptors in rats].
The administration of LHRH or of its analog [D-Ala6, des-Gly-NH10(2)] LHRH ethylamide to the female rat on day 10 of gestation resulted in termination of pregnancy and in a marked decrease in ovarian LH receptors and plasma progesterone level. Asingle injection of either compound during diestrus I also led to a decrease in LH receptors. These data demonstrate the high sensitivity of the control of ovarian LH receptors by circulating gonadotrophins and suggest that the contraceptive action of pre- and postcoitally administered LHRH is mediated by negative control of LH receptors.
Gonadotropin-Releasing Hormone, Receptors, Estrogen, Pregnancy, Ovary, Animals, Female, Receptors, Cell Surface, Fetal Resorption, Follicle Stimulating Hormone, Luteinizing Hormone, Progesterone, Rats
Gonadotropin-Releasing Hormone, Receptors, Estrogen, Pregnancy, Ovary, Animals, Female, Receptors, Cell Surface, Fetal Resorption, Follicle Stimulating Hormone, Luteinizing Hormone, Progesterone, Rats
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