This thesis studies a class of optimisation algorithms, namely Memetic Computing Structures, and proposes a novel set of promising algorithms that move the first step towards an implementation for the automatic generation of optimisation algorithms for continuous domains. This thesis after a thorough review of local search algorithms and popular meta-heuristics, focuses on Memetic Computing in terms of algorithm structures and design philosophy. In particular, most of the design carried out during my doctoral studies is inspired by the lex parsimoniae, aka Ockham’s Razor. It has been shown how simple algorithms, when well implemented can outperform complex implementations. In order to achieve this aim, the design is always carried out by attempting to identify the role of each algorithmic component/operator. In this thesis, on the basis of this logic, a set of variants of a recently proposed algorithms are presented. Subsequently a novel memetic structure, namely Parallel Memetic Structure is proposed and tested against modern algorithms representing the state of the art in optimisation. Furthermore, an initial prototype of an automatic design platform is also included. This prototype performs an analysis on separability of the optimisation problem and, on the basis of the analysis results, designs some parts of the parallel structure. Promising results are included. Finally, an investigation of the correlation among the variables and problem dimensionality has been performed. An extremely interesting finding of this thesis work is that the degree of correlation among the variables decreases when the dimensionality increases. As a direct consequence of this fact, large scale problems are to some extent easier to handle than problems in low dimensionality since, due to the lack of correlation among the variables, they can effectively be tackled by an algorithm that performs moves along the axes.